​GC-SOS Gas Chromatography Simulation & Optimization Software
GC-SOS Gas Chromatography Simulation & Optimization Software. GC-SOS is a Windows app for the simulation and optimization of capillary gas chromatography separations.  It features a rich set of powerful functions in a package designed to be intuitive and easy to use. For GC method development and teaching retention principles. Temperature, Pressure, Flow, Rate, Animation, Automatic Optimization Algorithm, flexible. GC Simulation, retention simulation

GC-SOS Flexible Input Requirements

​​We designed GC-SOS from the ground up to be easy to use!  You can use from 1 to 3 training runs to simulate your separation, depending upon the level of accuracy needed.  In many cases, your existing isobaric (constant pressure) separation can be used as a training run.

Flexible training run requirements.
A unique GC-SOS feature is the ability to use 1 to 3 training runs with up to 5 different temperature segments! No need to use only isothermal training runs or single ramp segments.  

Single training run capability.
We thought it ideal to be able to simulate from your existing isobaric separation without having to perform any additional training runs.  GC-SOS is the only program that offers this valuable feature.  Through rigorous modeling of GC retention behaviour, we were able to develop a novel capability that can accurately predict retention from a single run.  We are actually surprised how accurate simulations can be made using just one training run.   When using only 1 training run, retention time prediction errors are often less than 5%.   A common strategy is to enter your existing separation and then optimize it using GC-SOS. Then re-run your separation using the new optimized conditions. This new run can then be entered into GC-SOS as a second training run for higher accuracy if desired. 

Higher accuracy predictions using multiple training runs.
Up to 3 training runs can be used, depending on the level of accuracy needed. The second run is used to improve temperature predictions, and the third run is used to improve pressure predictions. The simulation accuracy of GC-SOS depends upon many things. In most cases, when using 2 or more training runs, retention time prediction errors are less than ~1-2%. When using 2 or more training runs, we've found GC-SOS retention time simulations to be typically equal to, or better than competing programs.


How does it work?
  • A retention model is derived based on the run conditions and retention data from your separation.
  • Linear coefficients represent the base model for retention as a function of temperature in GC-SOS.
  • If 1 training run is used, both temperature and pressure coefficients are numerically estimated.
  • If 2 training runs are used, temperature coeffecients are exactly calculated, and pressure coefficients are estimated.
  • If 3 training runs are used, both  temperature and pressure coefficients are exactly calculated.

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​​ Feedback from GC-SOS users:

".. well designed and easy to use... an essential tool for method development."

" I like being able to make simulations based on my existing separation."

​"The Automatic-Optimization function is amazing!"

​".. more effective than traditional trial-and-error approaches."

" Our optimized separations are now significantly more efficient- saving both time and money."

​"We use GC-SOS in our Gas Chromatography training classes.""